Aristolochia contorta

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Nomenclature

Other Names:

Historical Use of Aristolochia contorta

Aristolochia contorta in Traditional Chinese Medicine

Background

Zhidouling Ö˶µÁå Chinese Name (pinyin): Madouling

Chinese Name  :

Common Name  :Aristolochia Fruit

Specific Name  : Fructus aristolochiae

Scientific Name:
Collection  : The drug is collected in autumn when the fruit turns from green to yellow and dried.

Description  : Ovoid, 3 - 7cm long, 2 - 4cm in diameter. Outer surface yellowish green, greyish green or brown with 12 longitudinal ribs from the extending numerous horizontal parallel veinlets. Apex flattened and obtuse, base with slender fruit stalk. Pericarp light and fragile, easily divided into 6 splitlings. Inner surface of pericarp smooth and lustrous with dense transverse veins. Fruit 6 locular, containing many seeds in each locule, ovelapped and arranged regularly. Seeds flattened and thin, obtuse triangular or fan shaped, 6 - 10mm long, 8 - 12mm wide, winged all around, pale brown, odour charactestic, taste slightly bitter.

Identification  : to 3g of the powder add 50ml of ethanol, heat under reflux on a water bath for 1 hour, filter. Evaporate the filtrate to dryness, dissolve the residue in 5ml of ethanol as the test solution. Extract the reference drug of Fructus Aristolochiae in the same manner, use the extract as the reference solution (1), use 0.5mg per ml solution of aristolochic acid CRS in ethanol as the reference solution (2). Carry out the method for thin chromatography (Appendix Vl B) using silica gel G as the coating substance and the upper layer of toluene-ethyl acetate water-formic acid (20:10:1:1) as the mobile phase. Apply in strip separately to the plate 5µl of each of the three solutions. After developing and removal of the plate, dry it in the air and examine under ultra violet light (365nm). The fluorescent strips in the chromatogram obtained with the test solution correspond in position and color to the strips in the chromatogram obtained with the reference solutions.

Processing  : Eliminate foreign matter, sift and rub the fruit to pieces.Processed with honey: Stri fry as describe under the method of stir frying with honey (Appendix ll D) until not sticky to fingers.

Action  : To remove heat from the lung and relieve cough and asthma, and to remove heat from the large intestine (rectum) for the treatment of hemorrhoid.

Indication  : asthma, cough, bloddy sputum due to heat in the lung; bleeding, swollen and painful hemorrhoids due to heat in the large intestine

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a dry place.

Tcm114.jpg
P61 1.jpg

Nomenclature

Other Names:

Historical Use of Aristolochia contorta

Aristolochia contorta in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Tianxianteng

Chinese Name  :

Common Name  :Dutchmanspipe Vine

Specific Name  : Herba aristolochiae

Scientific Name:
Collection  : The drug is collected in autumn, remove from foreign matter and dried in the sun

Description  : Stem slenderly cylindrical, slightly twisted, 1 - 3mm in diameter, externally yellowish green or pale yellowsih brown with longitudinal ridges and nodes, internodes varying in length, texture fragile, easily broken. Fracture exhibiting several vascular bundles of variable size. Leaves alternate, mostly crumpled, broken when whole, deltoid-narrow-ovate and cordate at the base. Dark green or pale yellowish brown, basal ones obviously veined, slenderly petioled, odor delicately aromatic and taste weak.

Identification  : Stem slenderly cylindrical, slightly twisted, 1 - 3mm in diameter, externally yellowish green or pale yellowsih brown with longitudinal ridges and nodes, internodes varying in length, texture fragile, easily broken. Fracture exhibiting several vascular bundles of variable size. Leaves alternate, mostly crumpled, broken when whole, deltoid-narrow-ovate and cordate at the base. Dark green or pale yellowish brown, basal ones obviously veined, slenderly petioled, odor delicately aromatic and taste weak.

Processing  : Elminate foreign matter and cut into sections.

Action  : To promote the flow of qi and blood, and to induce diuresis.

Indication  :

Precautions  :

Dosage  : 4.5 to 9 g.

Storage  : Preserve in a dry place, protected from mould.

Synonymns for Aristolochia contorta

Patent Medicines and Medicines with Multiple Ingredients that include Aristolochia contorta

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Aristolochia contorta in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

O V Nakonechnaya, A V Kalachev
Pollen ultrastructure in Aristolochia manshuriensis and A. contorta (Aristolochiaceae).
Protoplasma: 2018, 255(5);1309-1316
[PubMed:29511834] [WorldCat.org] [DOI] (I p)

Hao-Wei Ma, Cun-Zhu Dong, Xue-Ming Zhou, Miao-Miao Bu, Sen-Quan Yu
Aristololactam derivatives from the fruits of Aristolochia contorta Bunge.
Nat. Prod. Res.: 2018, 32(21);2505-2509
[PubMed:29313366] [WorldCat.org] [DOI] (I p)

Jianguo Zhou, Xinlian Chen, Yingxian Cui, Wei Sun, Yonghua Li, Yu Wang, Jingyuan Song, Hui Yao
Molecular Structure and Phylogenetic Analyses of Complete Chloroplast Genomes of Two Aristolochia Medicinal Species.
Int J Mol Sci: 2017, 18(9);
[PubMed:28837061] [WorldCat.org] [DOI] (I e)

Wen-Wen Mao, Wen Gao, Zhi-Tao Liang, Ping Li, Zhong-Zhen Zhao, Hui-Jun Li
Characterization and quantitation of aristolochic acid analogs in different parts of Aristolochiae Fructus, using UHPLC-Q/TOF-MS and UHPLC-QqQ-MS.
Chin J Nat Med: 2017, 15(5);392-400
[PubMed:28558875] [WorldCat.org] [DOI] (I p)

Jie Yu, Chao-Mei Ma, Xuan Wang, Ming-Ying Shang, Masao Hattori, Feng Xu, Yu Jing, Shi-Wen Dong, Yu-Qiong Xu, Cui-Ying Zhang, Shao-Qing Cai
Analysis of aristolochic acids, aristololactams and their analogues using liquid chromatography tandem mass spectrometry.
Chin J Nat Med: 2016, 14(8);626-40
[PubMed:27608953] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects