Angelica sinensis

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Nomenclature

Other Names:

Historical Use of Angelica sinensis

Angelica sinensis in Traditional Chinese Medicine

Background

Dangguishen µ±¹éÉí Dangguiwei µ±¹éβ Jiudanggui ¾Æµ±¹é Quandanggui È«µ±¹é Chinese Name (pinyin): Danggui

Chinese Name  :

Common Name  :Chinese Agelica Root

Specific Name  : Radix angelicae sinensis

Scientific Name:
Collection  : The drug is collected in late autumn, removed from rootlet and soil, slightly dried and tied up in small bundles, place on a shelf and smoke dried.

Description  : Somewhat cylindrical, 3 - 5 or more branched at the lower part, 15 - 25 cm long. Externally yellowish brown to brown, longitudinally wrinkled and transversely lenticellate. Root stocks (Guitou). 1.5 - 4 cm in diameter, annulated, apex obtuse and rounded, showing purple or yellowish green remains of stem and leaf sheaths, main roots (Guishen) lumpy on the surface, branching roots (Guiwei) 0.3 - 1 cm in diameter, the upper portion thick and thelower portion thin, mostly twisted and exhibiting a few rootlet scars. Texture flexible, fracture yellowish white or yellowish brown, bark thick showing some clefts and numerous brown dotted secretory cavities, wood paler in colour, cambium ring yellowish brown. Odour strongly aromatic, taste sweet, pungent and slightly bitter. It is not use medicinally if the roots become woody withered not oily or greenish brown on the fracture.

Identification  : Transverse section: Cork cells in several layers. Cortex narrow, scattered with a few oil cavities. Phloem broad, more cleft, oil cavities and oil tubes subrounded, 25 - 160µm in diameter, relatively large on the outer side, gradually becoming small inwards, surrounded by 6 - 9 secretory cells. Cambium in a ring, xylem rays 3 - 5 rows of cells wide, vessels singly scattered or 2 - 3 grouped, arranged radially, parenchymatous cells containing starch granules.Powder: Yellowish brown, parenchymatous cells in phloem fusiform, walls slightly thickened with very fine oblique crisscross striations, sometimes thin transverse septa visible. Scalariform and reticulate vessels frequently up to 80 µm in diameter. Sometimes fragments of oil cavities visible.Total ash: Not more than 7.0% (Appendix lX K)Acid-insoluble ash: Not more than 2.0% (Appendix lX K)Extractives: Carry out the hot extractives method as described under the determination for ethanol-soluble extractives (Appendix X A), using 70% ethanol as solvent not less than 45.0%.

Processing  : Eliminate foreign matter, wash, soften thoroughly, cut into slices and dry in the sun or at a low temperature.Stir fried with wine: Stir fry the slices as described under the method for stir frying with wine (Appendix ll D) to dryness.

Action  : To enrich blood, activate blood circulation, regulate menstruation, relieve pain, and relax bowels.

Indication  : anemia with dizziness and palpitation; mentstrual disorders, amenorrhea, dysmenorrhea; constipation; rheumatic arthralgia; traumatic injuries; carbuncles, boils, sores stir-fried with wine: amenorrhea, dysmenorrhea, rheumatic arthralgia, traumatic injuries

Precautions  :

Dosage  : 4.5 to 9 g.

Storage  : Preserve in a cool and dry place, protected from moisture and moth.

Synonymns for Angelica sinensis

Patent Medicines and Medicines with Multiple Ingredients that include Angelica sinensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Angelica sinensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Yanxia Zhang, Yaming Zhang, Yanming Han, Ye Tian, Pengcheng Wu, Aiyi Xin, Xiaoning Wei, Yanbin Shi, Zhenchang Zhang, Gang Su, Yanping Shi, Junxi Liu
Pharmacokinetics, tissue distribution, and safety evaluation of a ligustilide derivative (LIGc).
J Pharm Biomed Anal: 2020, 182;113140
[PubMed:32036300] [WorldCat.org] [DOI] (I a)

Weibin Qian, Xinrui Cai, Qiuhai Qian, Dongli Wang, Lei Zhang
Angelica Sinensis Polysaccharide Suppresses Epithelial-Mesenchymal Transition and Pulmonary Fibrosis via a DANCR/AUF-1/FOXO3 Regulatory Axis.
Aging Dis: 2020, 11(1);17-30
[PubMed:32010478] [WorldCat.org] [DOI] (P e)

Guang Yu, Yuan Zhou, Juanjuan Yu, Xueqin Hu, Ye Tang, Hui Yan, Jinao Duan
Author Correction: Transcriptome and digital gene expression analysis unravels the novel mechanism of early flowering in Angelica sinensis.
Sci Rep: 2020, 10(1);1888
[PubMed:32005842] [WorldCat.org] [DOI] (I e)

Diao Hui, Tan Rui-Zhi, Li Jian-Chun, Zhong Xia, Wen Dan, Fan Jun-Ming, Wang Li
Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation.
J Ethnopharmacol: 2020, 252;112637
[PubMed:32004631] [WorldCat.org] [DOI] (I a)

Chin-Yi Cheng, Shung-Te Kao, Yu-Chen Lee
Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats.
J Ethnopharmacol: 2020, 252;112612
[PubMed:31988015] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects