Angelica dahurica

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Nomenclature

Other Names:

Historical Use of Angelica dahurica

Angelica dahurica in Traditional Chinese Medicine

Background

Hangbaizhi º¼°×ÜÆ Xiangbaizhi Ïã°×ÜÆ Chinese Name (pinyin): Baizhi

Chinese Name  :

Common Name  :Dahurian Angelica Root

Specific Name  : Radix angelicae dahuricae

Scientific Name:
Collection  : The drug is collected in summer and autumn when leaves turns yellow, removed from rootlet and soil and dried in the sun or at a low temperature.

Description  : Long conical, 10 - 25cm long, 1.5 - 2.5 cm in diameter. Externally greyish brown or yellowish brown. The root stock obtusely quadroangular or subrounded with longitudinal wrinkles, rootlets scars and lenticels like transverse protrudings. Some of them arranged in 4 longitudinal rows. Apex with dented stem scars. Texture compact, fracture white or greyish white and starchy, cambium ring brown, subsquare or subrounded, scattered with many brown oil dots in bark. Odour aromatic, taste pungent and bitterish.

Identification  : 1.To 0.5g of the powder add 3 ml of ether, shake for 5 minutes, allow to stand for 20 minutes. To 1 ml of the supernatant add 2 - 3 drops of each 7% solution of hydroxylamine hydrochloride in methanol and 20% solution of potassium hydroxide in methanol, mix well, heat gently on a water bath, cool, adjust to pH 2 - 4 with dilute hydrochloric acid and then add 1 - 2 drops of 1% solution of ferric chloride in ethanol, a violet red colour is produced.2.To 0.5g of the powder, add 3 ml of water, shake, filter and add 2 drops of the filtrate to a piece of filter paper. Examine under ultra violet light (365 nm), a blue fluorescence is produced.3.To 0.5g of the powder add 10ml of ether, soak for 1 hour and shake frequently, filter, evaporate the filtrate to dryness. Dissolve the residue in 1 ml of ethyl acetate and use it as the test solution. Dissolve imperatorin CRS and isoimperatorin CRS in ethyl acetate to produced a solution of each of 1 mg per ml and used it as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing carboxymethylcellulose, sodium as the coating substance and petroleum ether (30 - 60ºC)-ether (3:2) as the mobile phase. Apply 4 µl of each of the solutions to the plate. After developing at 25ºC and removal of the plate, dry it in the air, examine under ultra violet light (365 nm). The fluorescent spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.4.Total ash: Not more than 6.0% (Appendix lX K)Acid-insoluble ash: Not more than 2.0%

Processing  :

Action  : To dispel wind, to remove damp, to clear the stuffed nose, to relieve pain, and to promote the subsidence of swelling and drainage of pus.

Indication  : headache, particularly pain the forehead, stuffy nose due to colds; sinusitis; toothache; excessive leukorrhea; swelling and pain of sores and wounds

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a cool and dry place, protected from moth.

Synonymns for Angelica dahurica

Patent Medicines and Medicines with Multiple Ingredients that include Angelica dahurica

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Angelica dahurica in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Tan Zhang, Lei He, Wanlei Yang, Yanben Wang, Jiaxuan Peng, Peng Sun, Qichang Yang, Yewei Jia, Kanxian Zhao, Yu Qian
Byakangelicin inhibits IL-1β-induced mouse chondrocyte inflammation in vitro and ameliorates murine osteoarthritis in vivo.
Int. Immunopharmacol.: 2020, 85;106605
[PubMed:32485353] [WorldCat.org] [DOI] (I a)

Zhao Gao, Jiecheng Zhang, Li Wei, Xingping Yang, Yuan Zhang, Bo Cheng, Zehong Yang, Weihang Gao, Chunhui Song, Wei Miao, Kevin Williams, Changhui Liu, Qin Xu, Yongsheng Chang, Yong Gao
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.
Oxid Med Cell Longev: 2020, 2020;8026838
[PubMed:32454943] [WorldCat.org] [DOI] (I e)

Linlin Chen, Weiheng Xu, Quanjun Yang, Hong Zhang, Lili Wan, Bo Xin, Junping Zhang, Cheng Guo
Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3.
Pharmacol. Res.: 2020, 158;104871
[PubMed:32413482] [WorldCat.org] [DOI] (I a)

Ba Wool Lee, Thi Kim Quy Ha, Hyo Moon Cho, Jin-Pyo An, Seong Kyun Kim, Choong-Sik Kim, Eunhee Kim, Won Keun Oh
Antiviral activity of furanocoumarins isolated from Angelica dahurica against influenza a viruses H1N1 and H9N2.
J Ethnopharmacol: 2020, 259;112945
[PubMed:32389854] [WorldCat.org] [DOI] (I a)

Lan Yang, Qian Li, Yanmei Feng, Daiyu Qiu
##Title##
J Anal Methods Chem: 2020, 2020;8987560
[PubMed:32280555] [WorldCat.org] [DOI] (P e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects