- 1 Nomenclature
- 2 Historical Use of Alpinia katsumadai
- 3 Background
- 4 Pharmaceutical Information
- 5 Evidence or the Use of Alpinia katsumadai in the Treatment of Epilepesy
- 6 Safety
Historical Use of Alpinia katsumadai
Alpinia katsumadai in Traditional Chinese Medicine
Chinese Name (pinyin): Caodoukou
Chinese Name :
Common Name :Seed of Katsumada Galangal
Specific Name : Semen alpiniae katsumadai
Collection : The fruit is collected in summer and autumn, dried in the sun to near dryness or treated briefly in boiling water and half dried in the sun then removed from pericarp. The seed masses are gathered and dried in the sun.
Description : Seed masses sub-spheroidal. 1.5 - 2.7cm in diameter. Externally greyish brown, somewhat smooth with yellowish white septa in central part dividing the masses into 3 groups, each having numerous seeds agglunated closely. Seeds ovoid polyhedral, 3 - 5 mm long about 3 mm in diameter covered with brownish membranous aril, raphe occurring as a longitudinal furrow, hilum present at one end, texture hard on cutting in a half longitudinally along the raphe, the seed showing oblique cordate in shape in longitudinal view. Testa extending inward along the raphe and occupying about ½ of the surface area. Endodesperm greyish white, odor aromatic, taste pungent and slightly bitter.
Identification : 1.Transverse section: Sometimes remains of aril present consisting of polygonal thin walled cells. Epidermal cells of testa sub-rounded, walls relatively thickened, hypodermis consisting of 1 - 3 layers of parenchymatous cells, slightly elongated tangentially, pigment layer consisting of several layers of brown cells, scattered with 1 - 2 layers of sub-rounded oil cells, about 50 µm in diameter. Endotesta consisting of 1 layer of palisade stone cells, brownish red with heavily thickened inner and lateral walls and small lumen containing silica bodies. Cells of perisperm containing starch granules, prisms and a few small clusters of calcium oxalate. Cells of endosperm containing aleurone grains.Powder Yellowish brown, epidermal cells of testa, stripe shape in surface view, up to 30 µm in diameter. Slightly thick walled, usually vertical to hypodermal cells. Hypodermal cells prolate polygonal or sub-rectangular in surface view. Pigment cells shrivelled with indistinct layer border containing reddish brown contents and mostly broken into irregular masses of pigment. Oil cells scattered among the layers of pigment cells, subrounded or oblong and containing yellowish green oily contents. Thick walled cells of endotesta yellowish brown or reddish brown, polygonal in surface view with thickened and unlignified walls and lumina containing silica bodies. 1 layer and palisade like in section view with heavily thickened inner and lateral walls and lumina outward eccentric, containing silicaa bodies. Cells of perisperm filled with masses of starch granules, some containing fine prisms of calcium oxalate. Cells of endosperm containing aleurone grains and fixed oil droplets.2.To 1g of the powder add 5ml of methanol heat on a water bath with shaking for 5 minutes. Filter and the filtrate use as the test solution. Dissolve alpinetin CRS and cardamonin CRS in 5 ml of methanol to produce a solution containing 2 mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix lV B), using silica gel G as the coating substance and benzene-ethyl acetate-methanol (15:4:1) as the mobile phase. Apply separately to the plate 4 µl each of two solutions. After developing and removal of the plate, dry it in the air. Heat at 105ºC for about 5 minutes and examine under ultra violet light (365 nm). The pale blue fluorescent spot in the chromatogram obtained with the test solution correspond in position and color to the spot due to alpinetin in the chromatogram obtained with the reference solution. Then spray with 5% solution of ferric chloride in ethanol. Examine under daylight and the brown spot in the chromatogram obtained with the test solution corresponds in position and color to the spot due to cadamonin in the chromatogram obtained with the reference solution.Assay: Carry out the method for determination of volatile oil (Appendix X D). It contains not less than 1.0% (ml/g) of volatile oil.
Processing : Eliminate foreign matters, break into pieces before use.
Action : To remove damp, to invigorate the spleen function, to warm the stomach and to arrest vomiting.
Indication : accumulation of damp-cold in the spleen and the stomach manifested by epigastric distension, pain and cold feeling accompanied with belching, nausea, vomiting and anorexia
Dosage : 3 to 6 g.
Storage : Preserve in a cool and dry place.
Synonymns for Alpinia katsumadai
Patent Medicines and Medicines with Multiple Ingredients that include Alpinia katsumadai
Evidence or the Use of Alpinia katsumadai in the Treatment of Epilepesy
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
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