Alpinia katsumadai

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Other Names:

Historical Use of Alpinia katsumadai

Alpinia katsumadai in Traditional Chinese Medicine


Chinese Name (pinyin): Caodoukou

Chinese Name  :

Common Name  :Seed of Katsumada Galangal

Specific Name  : Semen alpiniae katsumadai

Scientific Name:
Collection  : The fruit is collected in summer and autumn, dried in the sun to near dryness or treated briefly in boiling water and half dried in the sun then removed from pericarp. The seed masses are gathered and dried in the sun.

Description  : Seed masses sub-spheroidal. 1.5 - 2.7cm in diameter. Externally greyish brown, somewhat smooth with yellowish white septa in central part dividing the masses into 3 groups, each having numerous seeds agglunated closely. Seeds ovoid polyhedral, 3 - 5 mm long about 3 mm in diameter covered with brownish membranous aril, raphe occurring as a longitudinal furrow, hilum present at one end, texture hard on cutting in a half longitudinally along the raphe, the seed showing oblique cordate in shape in longitudinal view. Testa extending inward along the raphe and occupying about ½ of the surface area. Endodesperm greyish white, odor aromatic, taste pungent and slightly bitter.

Identification  : 1.Transverse section: Sometimes remains of aril present consisting of polygonal thin walled cells. Epidermal cells of testa sub-rounded, walls relatively thickened, hypodermis consisting of 1 - 3 layers of parenchymatous cells, slightly elongated tangentially, pigment layer consisting of several layers of brown cells, scattered with 1 - 2 layers of sub-rounded oil cells, about 50 µm in diameter. Endotesta consisting of 1 layer of palisade stone cells, brownish red with heavily thickened inner and lateral walls and small lumen containing silica bodies. Cells of perisperm containing starch granules, prisms and a few small clusters of calcium oxalate. Cells of endosperm containing aleurone grains.Powder Yellowish brown, epidermal cells of testa, stripe shape in surface view, up to 30 µm in diameter. Slightly thick walled, usually vertical to hypodermal cells. Hypodermal cells prolate polygonal or sub-rectangular in surface view. Pigment cells shrivelled with indistinct layer border containing reddish brown contents and mostly broken into irregular masses of pigment. Oil cells scattered among the layers of pigment cells, subrounded or oblong and containing yellowish green oily contents. Thick walled cells of endotesta yellowish brown or reddish brown, polygonal in surface view with thickened and unlignified walls and lumina containing silica bodies. 1 layer and palisade like in section view with heavily thickened inner and lateral walls and lumina outward eccentric, containing silicaa bodies. Cells of perisperm filled with masses of starch granules, some containing fine prisms of calcium oxalate. Cells of endosperm containing aleurone grains and fixed oil droplets.2.To 1g of the powder add 5ml of methanol heat on a water bath with shaking for 5 minutes. Filter and the filtrate use as the test solution. Dissolve alpinetin CRS and cardamonin CRS in 5 ml of methanol to produce a solution containing 2 mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix lV B), using silica gel G as the coating substance and benzene-ethyl acetate-methanol (15:4:1) as the mobile phase. Apply separately to the plate 4 µl each of two solutions. After developing and removal of the plate, dry it in the air. Heat at 105ºC for about 5 minutes and examine under ultra violet light (365 nm). The pale blue fluorescent spot in the chromatogram obtained with the test solution correspond in position and color to the spot due to alpinetin in the chromatogram obtained with the reference solution. Then spray with 5% solution of ferric chloride in ethanol. Examine under daylight and the brown spot in the chromatogram obtained with the test solution corresponds in position and color to the spot due to cadamonin in the chromatogram obtained with the reference solution.Assay: Carry out the method for determination of volatile oil (Appendix X D). It contains not less than 1.0% (ml/g) of volatile oil.

Processing  : Eliminate foreign matters, break into pieces before use.

Action  : To remove damp, to invigorate the spleen function, to warm the stomach and to arrest vomiting.

Indication  : accumulation of damp-cold in the spleen and the stomach manifested by epigastric distension, pain and cold feeling accompanied with belching, nausea, vomiting and anorexia

Precautions  :

Dosage  : 3 to 6 g.

Storage  : Preserve in a cool and dry place.

Synonymns for Alpinia katsumadai

Patent Medicines and Medicines with Multiple Ingredients that include Alpinia katsumadai

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Alpinia katsumadai in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai
Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome.
Acta Pharm Sin B: 2019, 9(4);734-744
[PubMed:31384534] [] [DOI] (P p)

Tong-Gang Liu, Kai-Hui Sha, Li-Guo Zhang, Xian-Xian Liu, Fang Yang, Jin-Ying Cheng
Protective effects of alpinetin on lipopolysaccharide/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses.
Microb. Pathog.: 2019, 126;239-244
[PubMed:30414839] [] [DOI] (I p)

Yan-Jiao Yin, Chuan-Jiao Chen, Shi-Wei Guo, Ke-Ming Li, Yu-Nan Ma, Wu-Mei Sun, Fu-Rong Xu, Yong-Xian Cheng, Xian Dong
Front Plant Sci: 2018, 9;1346
[PubMed:30337932] [] [DOI] (P e)

Qi Lv, Can Shi, Simiao Qiao, Na Cao, Chunge Guan, Yue Dai, Zhifeng Wei
Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.
Cell Death Dis: 2018, 9(9);890
[PubMed:30166541] [] [DOI] (I e)

Xuezhi Zhao, Xiaohan Guo, Junhua Shen, Dingchao Hua
Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.
Mol Med Rep: 2018, 18(4);4030-4036
[PubMed:30132572] [] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects