Akebia trifoliata

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Other Names:

Historical Use of Akebia trifoliata

Akebia trifoliata in Traditional Chinese Medicine


Chinese Name (pinyin): Yuzhizi

Chinese Name  :

Common Name  :Akebia Fruit

Specific Name  : Fructus akebiae

Scientific Name:
Collection  : The drug is collected in summer or autumn when the fruit turned, greenish yellow, dried in the sun or treated in boiling water for a moment and dried in the sun.

Description  : Reniform or prolate-ellipsoidal, slightly curved, 3 - 9cm long, 1.5 - 3.5cm in diameter. Externally yellowish brown with deep irregular wrinkles. Apex obtuse exhibiting a fruit stalk scar at the base. Texture hard, sarcocarp pale yellow or yellowish brown, seeds numerous, flattened and prolate-ovoid, yellowish brown or purplish brown, lustrous and linearly striated. Odor slightly aromatic, taste bitter.

Identification  : Wash clean, dry in the sun and brak to pieces before use.

Processing  :

Action  : To regulate the flow of the liver qi, to promote blood circultaion and relieve pain, and to cause diuresis.

Indication  :

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a ventilated dry place.

Synonymns for Akebia trifoliata

Patent Medicines and Medicines with Multiple Ingredients that include Akebia trifoliata

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Akebia trifoliata in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Juan Niu, Yujuan Wang, Yaliang Shi, Xiaofei Wang, Zhimin Sun, Kunyong Huang, Chun Gong, Mingbao Luan, Jianhua Chen
Genome: 2019, 62(12);817-831
[PubMed:31491340] [WorldCat.org] [DOI] (I p)

Xiaoya Wang, Ningxiang Yu, Hailong Peng, Zhenying Hu, Yong Sun, Xuemei Zhu, Li Jiang, Hua Xiong
The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice.
Food Funct: 2019, 10(7);3977-3991
[PubMed:31204754] [WorldCat.org] [DOI] (I p)

Weikang Chen, Yangbin Zheng, Liang Yan, Mingming Yuan, Lan Ouyang, Jun Li, Guoping Zhou, Ruijian Zhong
Validated UHPLC-MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study.
Biomed. Chromatogr.: 2019, 33(10);e4585
[PubMed:31099065] [WorldCat.org] [DOI] (I p)

Ningxiang Yu, Xiaoya Wang, Fangjian Ning, Chengjia Jiang, Yanbin Li, Hailong Peng, Hua Xiong
Development of antibacterial pectin from Akebia trifoliata var. australis waste for accelerated wound healing.
Carbohydr Polym: 2019, 217;58-68
[PubMed:31079685] [WorldCat.org] [DOI] (I p)

Wen-Li Lu, Tao Yang, Qiu-Jia Song, Zhao-Qin Fang, Zhi-Qiang Pan, Cao Liang, Dong-Wei Jia, Pei-Ke Peng
Akebia trifoliata (Thunb.) Koidz Seed Extract inhibits human hepatocellular carcinoma cell migration and invasion in vitro.
J Ethnopharmacol: 2019, 234;204-215
[PubMed:30528882] [WorldCat.org] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects