Adenophora tetraphylla

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Other Names:

Historical Use of Adenophora tetraphylla

Adenophora tetraphylla in Traditional Chinese Medicine


Chinese Name (pinyin): Nanshashen

Chinese Name  :

Common Name  :Fourleaf ladybell Root

Specific Name  : Radix adenophorae

Scientific Name:
Collection  : The drug is collected in spring and autumn. Remove from rootlets, washed, deprived of the coarse bark while still fresh, wash again and dried

Description  : Conical or cylindrical, slightly curved, 7 - 27 cm long, 0.8 - 3 cm in diameter. Externally yellowish white or pale brownish yellow, usually exhibiting patches of bark in depressions, mostly with deeply depressed transverse striations appearing interrupted-annulated at the upper part with longitudinal striations and furrows at the lower part. Apex bearing one or two rhizomes. Texture light and spongy, easily broken, fracture uneven, yellowish white, much cleft, odourless, taste sweetish

Identification  : Heat 2 g of the coarse powder in 20 ml of water on a water bath for 10 minutes and filter. To 2 ml of the filtrate add 2 - 3 drops of 5% solution of a-naphthol in ethanol, mix well and add 0.5 ml of sulfuric acid slowly along the tube wall, a purplish red ring produced at the junction of the liquids. Heat 2 ml of the filtrate with 4 - 5 drops of alkaline cupric tartrate TS on a water bath for 5 minutes, a red precipitate of cuprous oxide is produced.

Processing  : Remove rhizomes, wash and soften thoroughly. Cut into thick slices and dry.

Action  : To nourish yin and remove heat from the lung, to relieve phlegm, and to reinforce qi.

Indication  :

Precautions  : Incompatible with Rhizoma et Radix Veratri.

Dosage  : 9 to 15 g.

Storage  : Preserve in a ventilated dry place, protected from moth.

Synonymns for Adenophora tetraphylla

Patent Medicines and Medicines with Multiple Ingredients that include Adenophora tetraphylla

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Adenophora tetraphylla in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Xunzhi Zhu, Yuxi Zhang, Xia Liu, Dianyun Hou, Ting Gao
Authentication of commercial processed Glehniae Radix (Beishashen) by DNA barcodes.
Chin Med: 2015, 10;35
[PubMed:26628908] [] [DOI] (P e)

K J Zhao, T T X Dong, X M Cui, P F Tu, K W K Tsim
Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains.
Am. J. Chin. Med.: 2003, 31(6);919-26
[PubMed:14992544] [] [DOI] (P p)

P Tu, L Xu, G Xu, N Tsuneo
[Histological studies on the roots of eighteen species of sect. microdiscus of the genus Adenophora].
Yao Xue Xue Bao: 1998, 33(5);379-88
[PubMed:12017007] [] (P p)

P Tu, L Xu, G Xu, N Tsuneo
[Histological studies on the roots of twelve species of Sect. Microdiscus and Sect. Adenophora of the genus Adenophora].
Yao Xue Xue Bao: 1998, 33(6);469-76
[PubMed:12016920] [] (P p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects