- 1 Nomenclature
- 2 Historical Use of Sophora tonkinensis
- 3 Background
- 4 Pharmaceutical Information
- 5 Evidence or the Use of Sophora tonkinensis in the Treatment of Epilepesy
- 6 Safety
Historical Use of Sophora tonkinensis
Sophora tonkinensis in Traditional Chinese Medicine
Chinese Name (pinyin): Shandougen
Chinese Name :
Common Name :Root of Tonkin Sophora
Specific Name : Radix sophorae tonkinensis
Collection : The drug is collected in autumn, removed from foreign matter, wash clean and dried.
Description : Rhizomes irregular nodular, bearing remains of stem at the apex and several roots at the lower part. Roots long-cylindrical, usually branched, varying in length, 0.7 - 1.5 cm in diameter, externally brown to dull brown with irregular longitudinal wrinkles and prominent transversal lenticels. Texture hard, uneasily broken, fracture brownish in bark and pale yellow in wood. Odour bean like, taste very bitter.
Identification : 1.Transverse section: Cork consisting of several 10 or more layers of cells. The outer 1 - 2 rows of cells in cortex containing prisms of calcium oxalate forming an interrupted ring of crystal cells with lignified and thickened walls. Fibre bundles scattered in cortex and phloem. Cambium in a ring. Xylem develop, rays 1 - 8 cells wide, vessels subrounded, mostly singly scattered or in groups of 2 or more, some containing yellowish brown contents. Xylem fibres grouped scattered. Parenchymatous cells filled with starch granules. A few cells containing prisms.2.Add a few drops of sodium hydroxide TS to the outer cortex, an orange red to blood red colour persists.3.To about 2 g of the powder add 70% ethanol, heat under reflux foe 30 minutes, filter, evaporate the filtrate to dryness. Dissolve the residue in 5 ml of 1% hydrochloric acid solution, filter. To 1 ml of the filtrate add 1 drop of mercuric potassium iodide TS, a distinct pale yellow precipitate is produced.4.Shake 0.5 g of the coarse powder with 10 ml of chloroform and 0.2 ml of concentrated ammonia TS for 15 minutes, filter, evaporate the filtrate to dryness. Dissolve the residue in 0.5 ml of chloroform as the test solution. Dissolve matrine CRS and oxymatrine CRS in chloroform to prepare a solution containing 1 mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carboxymethyl cellulose as the coating substance and chloroform-methanol-concentrated ammonia TS (8:2:0.2) as the mobile phase. Apply separately to the plate 1 - 2 µl of the test solution and 4 - 6 µl of the reference solution. After developing and removal of the plate, dry it in the air, spray with potassium iodobismuthate TS. The orange yellow spots in the chromatogram obtained with test solution correspond in position and color to the spots in the chromatogram obtained with the reference drug solution.
Processing : Eliminate foreign matter, soak, wash clean, soften thoroughly, cut into thick slices and dry it in the sun.
Action : To remove toxic heat, promote the subsidence of swelling, and soothe the sore throat.
Indication : sore throat, painful swelling of the gums to due accumulation of toxic heat
Dosage : 3 to 9 g.
Storage : Preserve in a dry place.
Synonymns for Sophora tonkinensis
Patent Medicines and Medicines with Multiple Ingredients that include Sophora tonkinensis
Evidence or the Use of Sophora tonkinensis in the Treatment of Epilepesy
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
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